Atrial fibrillation (AF) patients are routinely prescribed medications to prevent and treat complications,\nincluding those from common co-occurring comorbidities. However, adherence to such medications may be\nsuboptimal. Therefore, we sought to identify risk factors for general medication non-adherence in a population\nof patients with atrial fibrillation.\nMethods: Data were collected from a large, ethnically-diverse cohort of Kaiser Permanente Northern and Southern\nCalifornia adult members with incident diagnosed AF between January 1, 2006 and June 30, 2009. Self-reported\nquestionnaires were completed between May 1, 2010 and September 30, 2010, assessing patient socio-demographics,\nhealth behaviors, health status, medical history and medication adherence. Medication adherence was assessed using a\npreviously validated 3-item questionnaire. Medication non-adherence was defined as either taking medication(s) as the\ndoctor prescribed 75% of the time or less, or forgetting or choosing to skip one or more medication(s) once per week or\nmore. Electronic health records were used to obtain additional data on medical history. Multivariable logistic regression\nanalyses examined the associations between patient characteristics and self-reported general medication adherence\namong patients with complete questionnaire data.\nResults: Among 12,159 patients with complete questionnaire data, 6.3% (n = 771) reported medication non-adherence.\nMinority race/ethnicity versus non-Hispanic white, not married/with partner versus married/with partner, physical inactivity\nversus physically active, alcohol use versus no alcohol use, any days of self-reported poor physical health, mental health\nand/or sleep quality in the past 30 days versus 0 days, memory decline versus no memory decline, inadequate versus\nadequate health literacy, low-dose aspirin use versus no low-dose aspirin use, and diabetes mellitus were associated with\nhigher adjusted odds of non-adherence, whereas, ages 65-84 years versus < 65 years of age, a Charlson Comorbidity\nIndex score����
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